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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Occludin: a gatekeeper of brain Infection by HIV-1

Fig. 3

Proposed model of signaling pathways influencing HIV-1 infection by modulation of occludin expression and function. Occludin functions are regulated by phosphorylation processes. Src, PKC, Rho-ROCK, VEGF, and PI3K-AKT-PTEN kinases can both alter occludin phosphorylation status and influence HIV-1 infection in several cell types. We propose that occludin phosphorylation may serve as one of the targets to modulate HIV-1 infection

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Fluids and Barriers of the CNS

ISSN: 2045-8118