Association between ventricular CSF biomarkers and outcome after shunt surgery in idiopathic normal pressure hydrocephalus

Table 5 Multivariate linear regression analysis on n = 114 patients with ventricular CSF biomarkers showed an adjusted R² of 0.061 and a statistical significance of p = 0.047

	Pearson R	Unstandardized β coefficients	95% CI	p‡
Constant		35.108	0.134 to 70.082	0.049
GFAP	− 0.158	− 7.002	− 13.743 to − 0.260	0.042
T-tau	0.161	4.772	− 14.262 to 23.806	0.620
Neurogranin	0.171	1.067	− 22.890 to 25.024	0.930
Age	− 0.184	− 220	− 0.493 to 0.053	0.114
Sex	− 0.154	3.137	− 7.028 to 0.755	0.113
Vascular risk factors	− 0.035	0.187	− 3.976 to 4.349	0.929

Biomarkers transformed by log10, and age, sex, and vascular risk factors as independent variables, and outcome on the iNPH scale score after shunt surgery as a dependent variable. Biomarkers selected had an alpha value of < 0.1 in the univariate regression. ‡ By Pearson correlation

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