Association between ventricular CSF biomarkers and outcome after shunt surgery in idiopathic normal pressure hydrocephalus

Table 4 Univariate linear regression analyses of biomarkers

	Pearson r	Unstandardized B	95% CI	Adjusted R²	P ‡
Aβ40	− 0.063	− 2.780	− 7.028 to 50.844	− 0.005	0.497
Aβ42	0.021	0.880	− 6.698 to 8.457	− 0.008	0.819
APPα	− 0.148	− 5.192	− 11.554 to 1.170	0.014	0.109
APPβ	− 0.086	− 4.184	− 12.285 to 3.917	− 0.001	0.351
P-tau	0.132	5.062	− 1.945 to 12.069	0.009	0.155
T-tau	0.169	5.246	− 0.361—10.853	0.020	0.066
NfL	− 0.112	− 4.609	− 12.146 to 2.928	0.004	0.228
GFAP	− 0.160	− 5.514	− 11.837 0.809	0.017	0.087
YKL40	− 0.061	− 3.190	− 12.857 to 6.476	− 0.005	0.515
MCP1	− 0.124	− 8.979	− 22.273 to 4.316	0.007	0.184
Neurogranin	0.181	7.095	− 0.029 to 14.218	0.024	0.051
GAP43	0.021	0.873	− 6.823 to 8.569	0.008	0.823

Ventricular CSF biomarkers as independent variables, transformed by log10, and delta iNPH scale score after shunt surgery as a dependent variable. ‡ By Pearson correlation

ISSN: 2045-8118