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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Proteomic interrogation of the meninges reveals the molecular identities of structural components and regional distinctions along the CNS axis

Fig. 5

Vimentin and cytokeratin identify trabecular and other meningeal cells. Immunofluorescence of mouse spinal meninges, performed as in Fig. 4. (a) Vimentin staining highlights cells within the SAS associated with trabeculae, as well as a thin layer of pial cells most closely apposed to the SAS. Keratin 76 (KRT76) staining is also seen in cells of the pia and arachnoid, as well as diffusely throughout the trabecular mesh, but does not overlap with vimentin. (b) Keratin 76 is associated with sheets of trabecular cells in addition to pial and arachnoid membranes. (c) Pancytokeratin staining of cellular sheets ( ←), characteristic of epithelial cells; cytokeratin-filled, cell processes (◆) may contribute to trabeculae of the filform type [4]. (d) Pancytokeratin staining of cells in the pia and arachnoid, and filamentous processes in the SAS; vimentin highlights cell bodies associated with trabeculae

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Fluids and Barriers of the CNS

ISSN: 2045-8118