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Table 1 Characteristics of all study participants

From: Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases

 

AD

MCI/AD

MCI

FTD

iNPH

C

n

21

21

22

13

72

21

Age, mean (SD)

71 (± 6)

71 (± 5)

72 (± 5)

68 (± 9)††

74 (± 6)

82 (± 4)***

Sex, Male (%)

11 (52)

10 (48)

11 (50)

9 (69)

48 (67)

12 (57)

T-tau (ng/L), mean (SD)

692 (± 302)*** n = 20

620 (± 258)***

265 (± 88)***

379 (± 163)*** n = 4

208 (± 152) n = 71

504 (± 262)*** n = 20

Aß-42 (ng/L), mean (SD)

398 (± 90)††† n = 20

428 (± 123)†††

826 (± 208)***

786 (± 217)*** n = 4

593 (± 153) n = 72

787 (± 287)** n = 20

  1. AD Alzheimer’s disease, MCI/AD mild cognitive impairment due to Alzheimer’s disease, MCI mild cognitive impairment, FTD frontotemporal dementia, T-tau total tau, Aß-42 Amyloid beta 42. Normal reference ranges: Aß-42: > 530 ng/L; T-tau: < 350 ng/L
  2. Higher than iNPH: * < 0.05; ** < 0.01; *** < 0.001
  3. Lower than iNPH: † < 0.05; †† < 0.01; ††† < 0.001