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Fig. 8 | Fluids and Barriers of the CNS

Fig. 8

From: Proteasome inhibition protects blood–brain barrier P-glycoprotein and lowers Aβ brain levels in an Alzheimer’s disease model

Fig. 8

BTZ effect on Aβ brain levels. A Western blot showing Aβ40 and Aβ42 protein expression levels in brain tissue samples from vehicle-treated hAPP mice, hAPP mice dosed with 0.25 mg/kg BTZ, and hAPP mice dosed with a combination of BTZ and CSA (0.25/25 mg/kg). β-Actin was used as protein loading control. B Aβ40 and C Aβ42 levels in pg/g brain tissue in brain tissue samples from hAPP, hAPP-BTZ, and hAPP-BTZ/CSA mice determined by ELISA. D Aβ42/Aβ40 ratio. Symbols indicate statistical groupings of pairwise comparisons adjusted for FDR. Columns that share a symbol do not significantly differ from each other

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Fluids and Barriers of the CNS

ISSN: 2045-8118