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Fig. 7 | Fluids and Barriers of the CNS

Fig. 7

From: Proteasome inhibition protects blood–brain barrier P-glycoprotein and lowers Aβ brain levels in an Alzheimer’s disease model

Fig. 7

BTZ effect on capillary Aβ levels. Representative confocal microscopy images of isolated brain capillaries immunostained for A Aβ40 (green: Aβ40; blue: nuclei counterstained with DAPI) and B Aβ42 (green: Aβ40; blue: nuclei counterstained with DAPI). Data after digital image analysis of membrane-associated C Aβ40- and D Aβ42-immunofluorescence using ImageJ. Statistics: Data per group are given as mean ± SEM for 10 capillaries from one preparation (pooled tissue: WT: n = 10 mice, hAPP: n = 15 mice, hAPP-BTZ: n = 15 mice, hAPP-BTZ + CSA: n = 15 mice). Shown are arbitrary fluorescence units (scale 0–255). Symbols indicate statistical groupings of pairwise comparisons adjusted for FDR. Columns that share a symbol do not significantly differ from each other

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Fluids and Barriers of the CNS

ISSN: 2045-8118