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Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Proteasome inhibition protects blood–brain barrier P-glycoprotein and lowers Aβ brain levels in an Alzheimer’s disease model

Fig. 6

BTZ effect on Aβ40 and Aβ42 plasma levels in hAPP mice. A Aβ40 (pg/ml) and B Aβ42 plasma levels (ng/dl) in samples from hAPP, hAPP-BTZ, and hAPP-BTZ/CSA mice. The overall tendency was for hAPP mice to have the lowest Aβ40 and Aβ42 plasma levels, which was significant for both Aβ forms. The difference between BTZ and BTZ/CSA was only significant for Aβ40. C Aβ42/Aβ40 ratios. No significant differences appeared by treatment. Symbols indicate statistical groupings of pairwise comparisons adjusted for FDR. Columns that share a symbol do not significantly differ from each other. hAPP: n = 16, hAPP-BTZ: n = 19, hAPP-BTZ + CSA: n = 18

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Fluids and Barriers of the CNS

ISSN: 2045-8118