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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Proteasome inhibition protects blood–brain barrier P-glycoprotein and lowers Aβ brain levels in an Alzheimer’s disease model

Fig. 5

BTZ effect on 20S proteasome activity levels in brain tissue and isolated capillaries. A Proteasome activity levels in brain tissue samples from WT, hAPP, hAPP-BTZ, and hAPP-BTZ/CSA mice. Brains were processed and assayed as described in the main text. No significant differences were found among the groups. B Increased proteasome activity levels in capillaries isolated from hAPP mice compared to capillaries from WT, hAPP-BTZ, and hAPP-BTZ/CSA mice. Samples were prepared and assayed as described in the text. For all assays, n = 3 per sample

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Fluids and Barriers of the CNS

ISSN: 2045-8118