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Fig. 9 | Fluids and Barriers of the CNS

Fig. 9

From: Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease

Fig. 9

Changes in ABC and SLC transporters in the brain capillaries of APP-KI mice. A–C Volcano plots of the identified ABC and SLC proteins in the brain capillaries of 2-, 5-, and 12-month-old mice. P-values estimated using Welch’s t-test were plotted against the fold change (APP-KI/WT) of protein expression for ABC and SLC transporter proteins in the isolated brain capillaries from age-matched mice. The horizontal line in each graph represents the level of significance (P < 0.01). The vertical line in each graph represents the fold change (1). D Age-dependent expression of differentially expressed ABC and SLC transporter proteins in the brain capillaries of APP-KI mice. Relative fold changes in protein expression (APP-KI/WT) in age-matched mice were calculated, and P-values were estimated using Welch’s t-test. Bars represent the mean ± SD values (n = 4–5). Plotted points represent individual values

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Fluids and Barriers of the CNS

ISSN: 2045-8118