Fig. 6

Changes in ribosomal protein expression in isolated brain capillaries of APP-KI mice. A Violin plots of protein expressions identified in “Cytoplasmic ribosomal proteins (WP163)” in the isolated brain capillaries of 2-, 5-, and 12-month-old APP-KI mice. Nineteen differentially expressed proteins were identified in the brain capillaries of APP-KI mice. Relative fold changes in protein expression (APP-KI/WT) in age-matched mice were calculated. Violin plot elements: center line, median; upper and lower lines, upper and lower quartiles. B Network analysis of the 19 differentially expressed proteins by STRING and GO analysis. C Age-dependent changes of differentially expressed proteins associated with “ribosome” in APP-KI mice. Closed circles indicate a significant difference between age-matched WT and APP-KI mice (P < 0.01); open circles indicate no significant difference. Bars represent the mean values. Plotted points represent individual proteins. Statistical significance was determined using one-way analysis of variance followed by Tukey’s post hoc test