Fig. 10

Changes in ABC and SLC transporter levels in APP-KI mouse brain. A–C Volcano plots of the identified ABC and SLC proteins in the brains of 2-, 5-, and 12-month-old mice. P-values estimated by Welch’s t-test were plotted against fold change (APP-KI/WT) of protein expression for ABC and SLC transporter proteins in the brain lysates of age-matched mice. The horizontal line in each graph represents the significance level (P < 0.01). The vertical line in each graph represents the fold change (1). D Age-dependent expression of differentially expressed ABC and SLC transporter proteins in the brains of APP-KI mice. Relative fold changes in protein expression (APP-KI/WT) in age-matched mice were calculated, and P-values were estimated using Welch’s t-test. SLC transporters were classified based on the cells primarily expressing them (endothelial cells [EC], neurons, astrocytes, and oligodendrocytes [ODG]), according to the RNA-seq database (26, 27). Bars represent the mean values (n = 4–5). Plotted points represent individual values