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Table 1 Papers for review

From: A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?

Authors

date

technique

patients / criteria

Age

years

controls

CBF

confounders

Foley [13]

1955

N2O washout

3 IIH

19,36,45

(35±11)

10

52%

 

Gado et al. [14]

1975

H215O first pass

7 IIH

12-73

-

-20%

no controls, underestimation of higher flows

Mathew et al. [15]

1975

Xe133 washout

2 IIH

23,32

-

-10%

no controls

Raichle et al. [16]

1978

H215O first pass

10 IIH

17-45

-

-19%

no controls, underestimation of higher flows

Gjerris et al. [17]

1985

Xe133washout

14 IIH

34±15

(43)

10

Normal

35% of patients ICP below 25 cmH20

Brooks et al. [18]

1985

C15O2first pass

5 IIH

27±1

(22-39)

15

Normal

IIH CO25.3 mmHg less than controls, underestimation of higher flows

Gross et al. [10]

1990

Xe133 washout

9 IIH

34±7

(40±20)

26

49%

 

Bicakci et al. [19]

2006

MR Gd first pass

14 IIH

37±9

(18-53)

14

Normal

all studies immediately after L.P., underestimation of higher flows

Bateman [6]

2008

MR Phase contrast

21 IIH stenosis

29±14

(31±13)

14

22%

 

Bateman et al. [7]

2009

MR Phase contrast

10 IIH patent

30 IIH stenosis

27±12

29±13

(31±13)

14

56%

23%

 

Alperin et al. [20]

2013

MR Phase contrast

11 IIH obese

29±9

(31±9)

11

Normal

Obese patients only

Levitt et al. [21]

2016

MRV manometry CFD

6 IIH stenosis

N/A

N/A

3

35%

Measured pressure/ stenosis and calculated flow

Capel et al. [22]

2018

MR Phase contrast

13 IIH

31±11

(37±7)

16

Normal

reported peak flow not mean flow, average pixel size 0.8 or 1.2 mm

Juhasz et al. [23]

2018

MR Phase contrast

20 IIH

34±14

(35±11)

20

Normal

pixel size 2.2 × 2.2 mm is too coarse

  1. Note.- C15O2, radiolabeled carbon dioxide; CFD, computational fluid dynamics; cmH20, centimeters of water; CO2, carbon dioxide; Gd, gadolinium; H215O, radiolabeled water; ICP, intracranial pressure; IIH, idiopathic intracranial hypertension; L.P., lumbar puncture; mm, millimeters; mmHg, millimeters of mercury; MRV, magnetic resonance venography; N/A, not available; N2O, nitrous oxide; SSS, superior sagittal sinus; Xe133, radiolabeled xenon. Control ages in brackets, Papers highlighted in BOLD have problems with the technique selected or methodological issues and are deemed uninterpretable