Skip to main content
Fig. 7 | Fluids and Barriers of the CNS

Fig. 7

From: Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody

Fig. 7

Diagram of hypothesized mechanisms involved in BBB transcytosis of mTfR-and-P2X7-receptor binding nanobody constructs. Anti-mTfR nanobodies bind to mTfR in blood and constructs are endocytosed. Nanobody constructs unbind from mTfR in a pH-dependent fashion in intracellular vesicular compartments. Nanobody constructs are released into the brain and bind P2X7 receptor targets. (Produced using BioRender)

Back to article page

Fluids and Barriers of the CNS

ISSN: 2045-8118