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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody

Fig. 2

M1 mTfR binding nanobody–NT fusions for assessment of central nervous system target engagement. Blinded assessment of M1 variants injected iv into wild-type mice (n = 3/group). M1 and M1P96H mutant caused modest hypothermia at 600 nmol/kg. M1AA (non TfR binding) TfR caused no detectible hypothermia. M1R56H, P96H, Y102H caused pronounced hypothermia at 25 nmol/kg

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Fluids and Barriers of the CNS

ISSN: 2045-8118