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Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Characterization of choroid plexus in the preterm rabbit pup following subcutaneous administration of recombinant human IGF-1/IGFBP-3

Fig. 6

Schematic illustration of the main findings in the present study. Subcutaneous administration of rhIGF-1/rhIGBP-3 to preterm rabbits (E29), results in a higher level of IGF-1 in serum and CSF at postnatal age at administration of 0 h compared to 24 and 72 h. This is in turn correlated with an increased IGF-1R activation in the ChP at a postnatal age of 5 h, and expression of genes involved in the ChP development. Stimulating ChPE cells with rhIGF-1/rhIGFBP-3 or rhIGF-1 results in an activation the IGF-1R and an increase in protein synthesis involved in ATP production and mRNA processing

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Fluids and Barriers of the CNS

ISSN: 2045-8118