Fig. 3

Simulations of transport by extracellular diffusion alone predict delayed influx and efflux compared to clinical observations, with delayed efflux also for enhanced diffusion. A Subject-specific computational brain mesh with segmentation of the cerebral cortex (blue) and subcortical white matter (green); B simulated tracer distribution after 24 h in a sample subject; C–D predicted versus observed group–averaged amount of tracer in the cerebral cortex (C) and subcortical white matter (D) under extracellular diffusion (\(\alpha =1\)) and enhanced diffusion (\(\alpha > 1\)). Error bars represent standard deviation