Fig. 1

SHRs display ventricular enlargement and excessive brain water accumulation. a Brain water content quantified from WKY rats (n = 5) and SHRs (n = 5) using the wet and dry brain weight. b Representative ICP traces for one WKY rat and one SHR. Arrow indicates injection of 5 µl aCSF to assure proper ICP reading. c Baseline ICP in WKY rats (n = 6) and SHRs (n = 6) quantified from a stable 20 min time period. d Brain weight of WKY rats (n = 5) and SHRs (n = 5) assessed post mortem. e Representative MRI brain sections (2D axial plane and 3D projections) of one WKY rat and one SHR demonstrating the lateral ventricle volume (purple), third ventricle volume (turquoise), and fourth ventricle volume (blue). f Lateral ventricle volumes of WKY rats (n = 5) and SHRs (n = 5) quantified from MRI. g Brain volumes of WKY rats (n = 5) and SHRs (n = 5) quantified by MRI. Error bars represent standard deviation and statistical significance was tested with an unpaired two-tailed t-test or a Mann-Whitney test depending on normality. *P < 0.05, **P < 0.01, *** P < 0.001, NS = not significant