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Fig. 8  | Fluids and Barriers of the CNS

Fig. 8 

From: Ultrasound-mediated blood–brain barrier opening uncovers an intracerebral perivenous fluid network in persons with Alzheimer’s disease

Fig. 8 

A network of perivenous spaces is identified on post-mortem brain specimens and corresponds anatomically with observed regions of MRI perivenous enhancement. Mild pitting is noted on coronal brain slices and is more prominent in persons with Alzheimer’s disease. A Boxed area in frontal subcortical region shows sampled region. On intermediate power microscopy images, perivenous spaces are noted. Perivenous spaces are shown to advantage on cropped images, which display mononuclear cells within the perivenous spaces (PVS). Plots summarize PVS size in frontal, parietal, and temporal regions of Alzheimer’s disease (AD) (n = 3) and non-AD (n = 3) decedents (B). Heterogeneity of immune cell density in PVS is shown in both AD and non-AD decedents (C)

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Fluids and Barriers of the CNS

ISSN: 2045-8118