Fig. 5

The mechanism-independent two-compartment model. A Scheme shows neocortex overlaid on an exemplary precontrast T1w axial MRI. The close-up illustrates exchange rates of k₁, k₂ between the two compartments, while CSF has to pass the outer regions of cortex to reach the inner regions and then has to pass the outer region again before being cleared from the brain. B % Difference between I_in^sol and I_in as a function of thickness of outer compartment. Each data point was calculated using the average TSC from n = 49 animals. Minimum difference (indicated in red) was observed with a thickness of 4 voxels for the outer compartment. Table shows relation between number of voxels and compartment volume relative to total neocortex volume