Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus

Table 3 Top ten list of biomarker candidates most significantly changed between shunt-responsive and shunt-unresponsive iNPH patients

Accession	Gene Symbol	p-value	FDR-adjusted p-value	log₂(fold change)
P05413	FABP3	< 0.001	0.025	− 0.25
P62328	TMSB4X	< 0.001	0.065	− 0.23
O43491	EPB41L2	< 0.001	0.065	0.27
P62258	YWHAE	< 0.001	0.065	− 0.18
P14174	MIF	< 0.001	0.065	− 0.20
Q9HDC9	APMAP	< 0.001	0.078	0.50
Q9NPZ5	B3GAT2	< 0.001	0.078	0.20
P54652	HSPA2	< 0.001	0.078	− 0.21
P02655	APOC2	< 0.001	0.078	0.71
P09525	ANXA4	< 0.001	0.078	0.32

List of top ten biomarker candidates to predict shunt responsiveness in iNPH patients 1 year post-shunting identified via analysis of covariance (ANCOVA), employing age and sex as covariates. Patients were grouped into shunt-responsive (n = 35) and unresponsive (n = 33) according to their clinical improvement on the iNPHGS 1 year after shunt installation. P-values were adjusted using Benjamini–Hochberg correction. Biomarker candidates overlapping with the top ten list obtained through correlation analysis are marked in blue

ISSN: 2045-8118