Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus

Table 2 Top ten list of biomarker candidates correlating most strongly with iNPHGS change 1 year post-shunting

Accession	Gene symbol	Spearman correlation coefficient R	p-value	FDR-adjusted p-value
P14174	MIF	− 0.49	< 0.001	0.046
P05413	FABP3	− 0.46	< 0.001	0.067
P16152	CBR1	− 0.44	< 0.001	0.080
P09525	ANXA4	0.46	< 0.001	0.080
Q9NPZ5	B3GAT2	0.54	< 0.001	0.080
Q9UJ14	GGT7	− 0.46	< 0.001	0.080
A0A0B4J1V7	IGHV7-81	0.42	< 0.001	0.080
P37837	TALDO1	− 0.42	< 0.001	0.080
P06744	GPI	− 0.42	< 0.001	0.080
P06733	ENO1	− 0.42	< 0.001	0.080

List of top ten biomarker candidates to predict shunt responsiveness in iNPH patients 1 year post-shunting identified via Spearman rank-order correlation. Protein abundances were correlated with the patient’s corresponding improvement on the iNPHGS 1 year after shunt installation. P-values were adjusted using Benjamini–Hochberg correction. Biomarker candidates overlapping with the top ten list obtained through ANCOVA analysis are marked in blue

ISSN: 2045-8118