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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus

Fig. 1

Correlation of top nine biomarker candidates with iNPHGS change. Spearman rank-order correlations of CSF FABP3 (A), MIF (B), ANXA4 (C), B3GAT2 (D), ITGB1 (E), YWHAG (F), OLFM2 (G), TGFBI (H), and DSG2 (I) with clinical improvement on the iNPH grading scale (iNPHGS) 1 year post-surgery. Clinical improvement was calculated by subtracting the iNPHGS measurement 1 year after shunt installation from the iNPHGS score baseline measurement so that a score change of >  = 1 (vertical dashed line) corresponded to a clinically significant shunt response. Points colored in gray represent measurements stemming from iNPH patients with a concomitant neurodegenerative disease. Displayed p-values were not FDR-corrected. The gray shading around the fitted line indicates the 95% confidence interval of the fit

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Fluids and Barriers of the CNS

ISSN: 2045-8118