Fig. 2
From: Glucocorticoids modify intracranial pressure in freely moving rats
Chronic corticosterone lowers ICP
Female rats implanted with ICP telemeters treated with either vehicle (2.5% ethanol) or corticosterone (CORT) (400 mg/L) in their drinking water over 28 days. A) Study design diagram. B) ICP trace of implanted rats over 28 days displaying whole day ICP means. C) Mean ICP from day 0-9 in implanted rats. D) Mean ICP from day 10-28 in implanted rats.' E) Mean ICP day of 5 days with ICP periodicity lines. F) Light dark differences In ICP. G) Mean daily ICP spikes, average of 5 days with periodicity lines. H) ICP spikes in light and dark, and I) total daily spikes. J) Scatter graph of hourly ICP spikes vs. ICP relative to mean. Students t-test for C,D and I. Repeated measures ANOVA with Sidak’s test for B, and F. Spearman’s correlation coefficient for I. N = 6 for B-H, N = 24 for J. **=P < 0.01, ***=P < 0.001 and ****=P < 0.0001. Data presented as mean ± SEM, mean for F