Fig. 1

Acute prednisolone reduces ICP

Female rats implanted with ICP telemeters treated with either vehicle (0.9% saline) or prednisolone (PRED) (100 mg/kg) administered via oral gavage in a sequential study. A) Study design diagram. B) Baseline ICP at each treatment for preceding 24 h. C) ICP trace displaying 1-hour ICP means 24 h prior to and after oral gavage (graph break), with inset displaying baseline ICP. D) ICP spikes in the 24 h prior to and after oral gavage in both vehicle and PRED treated rats. Temporal spectrograms of fast Fourier transformed ICP traces in 0.25 Hz frequency bins of Veh E) and PRED F) treatment. G) Spectral power over 24 h relative to baseline for slow ICP waves (0-0.25 Hz). Two-way repeated measures ANOVA with post-hoc Sidak’s tests for C, D and G. Unpaired t-test for B. N = 6. **=P < 0.01, ***=P < 0.001 and ****=P < 0.0001. Data presented as mean ± SEM and mean for E and F