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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1

Fig. 2

NKCC1 conditional knockdown in ChP delays perinatal CSF potassium clearance (A) Schematic of ICV injection of AAV2/5 AAV-Cre vs. AAV-Null (empty) viral vectors at E14.5 followed by analysis of CSF, ChP, and cortex at P4. (B) CSF [K+] was significantly elevated at P4 from mice with NKCC1 knockdown as determined by ICP-OES. N = 6 for AAV-empty; N = 8 for AAV-Cre. (C) No other transporters or channels that modulate K+ were changed after NCKK1 knockdown. * p < 0.05, ** p < 0.01. Welch’s t-test

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Fluids and Barriers of the CNS

ISSN: 2045-8118