Fig. 1

HFD leads to increased bodyweight and intracranial pressure in female rats. A Bodyweight increase as a function of time of all control (n = 14) and HFD-fed (n = 17) rats included in the study with the visibly larger rats illustrated in B, the bodyweight at the time of experiments illustrated in C, and the BMI at the time of experiment illustrated in D. E Representative ICP traces of control and HFD-fed rats with the last 15 min employed for the quantification, summarized in F. G ICP correlates with bodyweight across control and HFD-fed rats (R² = 0.34, p < 0.05, n = 16). H Representative ICP trace with “raw” (blue line) and “smoothed” (red line) signals, the latter used to calculate the mean wave amplitude (MWA), represented in I (n = 7 af each). J Correlation analysis of MWA as a function of the ICP, n = 14, R² = 0.40, p < 0.05. Statistical significance evaluated with Student’s unpaired t-test and results shown as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001