Fig. 7
From: Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
a Plasma (%ID/g(bw)) concentrations, b percentage of bispecific antibody in the plasma fraction (%) c blood cell pellet (%ID/g(bw)) concentrations and d brain concentrations (%ID/g(bw)) after 0.05, 1 or 10 mg/kg-administration of [125I]mAb3D6-scFv8D3 in young WT mice. Significant differences were analysed by one-way ANOVA with Bonferroni's posthoc test. Significant p-value is defined as p < 0.05, *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001)