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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalus

Fig. 3

Microglial ablation does not improve grey matter thinning or white matter edema in prh mutants. A PLX-treated WT and prh mutant somatosensory cortex stained with DAPI (blue). Longer white double-sided arrow represents grey matter (GM) thickness, and smaller arrow represents white matter (WM) thickness. Scale bar = 500 μm. B Grey matter thickness. Thinner in untreated-prh compared, not improved by PLX5622 treatment. White matter thickness. Thicker in untreated-prh, which is not improved by PLX5622 treatment. PLX5622 has no effect on the thickness of white matter in WT. Total cortical thickness (grey matter thickness + white matter thickness). No statistically significant difference between treatment or genotype groups. Stats: two-way ANOVA followed by Tukey’s test, n ≥ 10 in each group, ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05

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Fluids and Barriers of the CNS

ISSN: 2045-8118