Central nervous system insulin signaling can influence the rate of insulin influx into brain

Table 3 ¹²⁵I-insulin blood-to-brain pharmacokinetics following ICV S961

Brain Region	Sex	Group	K_i (µl/g-min)	K_i p	r	V_i (µl/g)	V_i p
Whole Brain	Male	Vehicle	1.01 ± 0.26	0.143	0.80	3.2 ± 1.3	0.002
	Male	S961	0.66 ± 0.07	0.143	0.94	2.1 ± 0.6
	Female	Vehicle	2.15 ± 0.36	0.007	0.88	1.5 ± 1.7	-
	Female	S961	0.96 ± 0.17	0.007	0.87	2.2 ± 0.92
Olfactory Bulb	Male	Vehicle	2.72 ± 0.78	0.111	0.74	5.8 ± 3.7	0.040
	Male	S961	1.32 ± 0.41	0.111	0.70	5.5 ± 3.0
	Female	Vehicle	2.28 ± 0.48	0.418	0.85	4.9 ± 2.3	0.131
	Female	S961	1.73 ± 0.46	0.418	0.78	4.0 ± 2.3
Hypothalamus	Male	Vehicle	2.50 ± 0.71	0.084	0.74	2.7 ± 3.4	0.455
	Male	S961	1.00 ± 0.43	0.084	0.59	7.2 ± 3.4
	Female	Vehicle	6.42 ± 2.08	0.200	0.76	1.2 ± 4.8	0.036
	Female	S961	3.21 ± 0.91	0.200	0.78	-0.6 ± 4.4

ISSN: 2045-8118