Fig. 1
From: Central nervous system insulin signaling can influence the rate of insulin influx into brain
Distribution of 125I-insulin and 125I-S961 following ICV delivery. Distribution of (A)125I-insulin in serum and (B)125I-insulin or (C)125I-S961 throughout the brain was measured over time. There were significant differences over time for serum (one-way ANOVA *p < 0.05) and between brain regions (two-way ANOVA: time and region p < 0.05; post hoc analysis as marked: ap<0.05 hypothalamus vs. all other regions; bp<0.05 hypothalamus vs. hippocampus; cp<0.05 hypothalamus vs. olfactory bulb, frontal cortex, and cerebellum; dp<0.05 olfactory bulb vs. hippocampus, ep<0.05 hippocampus vs. olfactory bulb and frontal cortex; n = 2–4 /time point)