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Table 1 Reported repressors or enhancers of CLDN5 promoter

From: The CLDN5 gene at the blood-brain barrier in health and disease

Transcriptional factors

Ref

Enhancers

E26 transformation specific (ETS)-1

[31, 93]

ETS-related gene (ERG)

[29]

Sex-determining region Y-box 18 (SOX-18)

[28]

Kruppel-like factor 4

[30]

CCAAT/enhancer-binding protein-α (C/EBP-α)

[52]

Glucocorticoid receptor

[38]

Estrogen receptor β/Sp1

[39, 40]

Vitamin D response element

[41]

Repressors

NF-κB subunit p65 (RelA)

[46]

SMAD2/SMAD3/SMAD4/β-catenin

[90]

Runt-related transcription factors 1 (RUNX1)

[47]

ZONAB

[121]

β-catenin/FoxO1/Tcf4/Suz12/Ezh2/Eed

[57]

  1. Eed, embryonic ectoderm development; Ezh2, enhancer of zeste homolog 2; FoxO1, forkhead box protein O1; Suz12, suppressor of zeste 12; Tcf4, transcription factor 4; ZONAB, ZO-1-associated nucleic acid binding protein
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Fluids and Barriers of the CNS

ISSN: 2045-8118