Fig. 2

Simulated and in vivo normalised ADC^eq(t_m) and ADC’(t_m) at a range of slice thicknesses (∆z). a Simulated data with crushers off at ∆z = 10.0 mm showing the hypothetical ADC'(t_m) and ADC^eq(t_m) (red circles) behaviour without crusher gradients. Thinner slice thicknesses result in larger decreases in measured ADC^eq(t_m) (green circles), and more attenuated recovery of ADC'(t_m) (black dots), due to the larger crusher gradients. b–d Simulated data with active crushers on at ∆z = 10.0 mm, 4.0 mm, 2.5 mm. e, f In vivo data at ∆z = 4.0 mm and 2.5 mm. The AXR model (black solid line) was fit to mean normalised ADC’ with the mean ± standard error (s.e.m) across all animals (n = 5) with 95% confidence displayed (black dash). Different y-axis ranges are used for the normalised ADC’ for the simulated and in vivo data