Skip to main content

Table 1 Measurements of gross morphological parameters

From: Morphological and mitochondrial changes in murine choroid plexus epithelial cells during healthy aging

 

2 m.o.

8 m.o.

20 m.o.

Cell axis ratio

0.88 ± 0.04

0.72 ± 0.03*

0.78 ± 0.04*

Cell area (µm2)

86.5 ± 1.99

77.6 ± 2.11**

78.84 ± 1.92*

Microvilli surface (µm2)

20.35 ± 0.6

16.22 ± 0.49****

15.97 ± 0.49****

Microvilli length (µm)

1.26 ± 0.02

1.05 ± 0.02****

0.95 ± 0.02****; ##

Invagination area (µm2)

8.28 ± 0.54

19.66 ± 0.76****

22.54 ± 0.84****

Inclusion density (inclusion/µm2)

0.64 ± 0.13

2.05 ± 0.42**

2.2 ± 0.28****

Interrupted tight junctions (%)

17

42

41

Total length tight junctions (µm)

4.6 ± 0.14

4.14 ± 0.14

3.63 ± 0.16****

Total junctional contact area (µm)

4.32 ± 0.14

2.7 ± 0.1****

2.09 ± 0.1****; ##

Number of tight junction dilatations

0.42 ± 0.06

1.98 ± 0.12****

2.14 ± 0.13****

  1. Mean ± s.e.m. n = 30 cells per animal, 3 animals in each age group. *Statistical differences compared to 2 months old (m.o.), # to 8 m.o., Kruskal–Wallis test, *p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001