Are standing osmotic gradients the main driver of cerebrospinal fluid production? A computational analysis

Table 2 Parameters used in the 1D model with the corresponding references

Parameters	Symbol	Mean	SD	Distribution	References
Microvillus length (µm)	\({l}_{\text{mv}}\)	2	0.33		[1]
Microvillus radius (µm)	\({r}_{\text{mv}}\)	0.09	0.01		[6]
Microvilli surface density (1/µm²)	\(\sigma\)	12.5	1.83		[1]
ChP apparent area (cm²)	\({A}_{\text{app}}\)	3.66	0.35	Non-normal	[26,27,28]
Protected length (µm)	\({l}_{\text{prot}}\)	77.5	19.4		[25, 26, 28]
Diffusion coefficient (cm²/s)	\(D\)	1.15 × 10^–5	1.3 × 10^–6		[34, 35]
Bulk solute concentration (Osm)	\({C}_{0}\)	0.307	0.006		[36]
Luminal membrane permeability (cm/s · Osm)	\({L}_{\text{p}}\)	1.44 × 10^–5	6.42 × 10^–6	Non-normal	[6]
CSF density (g/mL)	\(\rho\)	1.00	0.0002		[37]
Measured CSF production rate (µL/min)	\({Q}_{\text{meas}}\)	6.8	0.3		[6]

For the 1D parameter values, references are indicated, and mean and standard deviation (SD) given. All directly measured parameters are assumed to be normally distributed. Some parameters calculated as a function of directly measured ones have non-normal distributions (indicated in Additional file 1: Table S1)

ISSN: 2045-8118