Fig. 1
From: Epigenetics and stroke: role of DNA methylation and effect of aging on blood–brain barrier recovery
Experimental flow chart. Young and old mice underwent thromboembolic (TE) stroke. At one and seven days they underwent T2 MRI and T1 MRI to determine infarct size and BBB permeability (influx rate constant, Ki) before euthanasia and microvessel isolation, respectively. Those microvessels were used to determine the methylome and transcriptome changes. Graph represents means ± SD, n = 5, **p < 0.01, ***p < 0.001, ****p < 0.0001. Created with BioRender.com