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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier

Fig. 5

Effect of bacterial PAMP exposure (LPS 0.01 µg/mL or vehicle for 24 h) on total ABCB1/ABCG2, cytokines and chemokine mRNA levels in human primary fetal brain endothelial cells (hfBECs) derived in early and mid-gestation. Relative ABCB1/ABCG2, cytokines (IL-6, IL-8, INFα) and chemokine (CCL2) mRNA expression in early (A–F) and mid- (G–L) gestation hfBECs. Data are expressed as means ± SD. N = 6/group (if N < 6, an outlier has been removed). Statistical differences were tested using a paired t-test. *p < 0.05. mRNA values from LPS and Poly I:C (Fig. 6) treated groups were compared to the same vehicle controls (treated with water)

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Fluids and Barriers of the CNS

ISSN: 2045-8118