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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells

Fig. 3

Tocilizumab decreases BSCB leakage in the injured epicenter after SCI. A, B Double immunostaining of fibrinogen (green) and CD31 (red) was used to examine BSCB permeability in the injured core at 14 (A) and 28 dpi (B) and in normal spinal cord tissue (sham). Fibrinogen leakage was severe in the PBS group in the injured core, while no obvious fibrinogen leakage is observed in the Tocilizumab and sham groups. Asterisks indicate the injured epicenter. Scale bar: 100 μm. C Quantitative analysis of the relative fluorescence intensity of leaky fibrinogen as shown in A and B. All images show sagittal sections. Data are presented as the mean ± SEM (n = 5 in each group). ****p < 0.001 (PBS vs. sham and Tocilizumab). #p < 0.05 (Tocilizumab vs. sham)

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Fluids and Barriers of the CNS

ISSN: 2045-8118