Fig. 2
ISF dialysate concentration of [125I]I-mAb3D6 and [125I]I-mAb3D6-scFv8D3 in the hippocampus was measured by microdialysis 0–6 h (a) or 24 h (b) post-injection. The concentration of [125I]I-mAb3D6-scFv8D3 and [125I]I-mAb3D6 was measured 6 h post-injection in wild-type (Wt) mice and 24 h post-injection in Wt and in AppNL−G−F mice in the brain (c), blood (d) and plasma (e). Brain to blood ratio is presented in f. Data is presented as mean ± SEM. a Repeated measures ANOVA; b–f one-way ANOVA with Tukey's post-hoc test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. n = 4–5 mice/group