Fig. 1

Exogenous laminins exhibit a vascular pattern in the brain via binding to their receptors rather than self-assembly. A Illustration of the structures of various wild-type and mutant laminins. B Representative low-magnification image showing the vascular pattern of intracerebrally injected laminins. C Representative images of Alexa-555 labeled laminins (red) and SMA (green) in the brain at 24 h after intracerebral injection. D Quantification of Alexa-555 fluorescent intensity in (C). n = 4, *p = 0.0286 compared to laminin-β1 counterparts by Mann–Whitney U test. ^#p = 0.0286 compared to their wild-type counterparts by Mann–Whitney U test. Data are represented as mean ± SD. SMA, α-smooth muscle actin