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Fig. 7 | Fluids and Barriers of the CNS

Fig. 7

From: Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus

Fig. 7

Changes in the expressions of the striatal dopaminergic and cholinergic neurotransmitter markers in hydrocephalic rats. A shows representative Western blots of the expression of TH in the striatum of hydrocephalic and age-matched control (n = 4–12 rats per group). B Representative TH immunolabeling from the dorsolateral striatum of the acute and chronic hydrocephalic (b1 and b2, respectively) and corresponding age-matched controls (b3 and b4) (n = 3 rats for each group). C–E are representative Western blots and corresponding analyses for the expressions of striatal DR1 and 2 and ChAT (n = 4–11 rats per group). The expression of the GAPDH is the internal gel-loading control. The expression of each protein was normalized to that GAPDH and presented as a ratio to that of the age-matched sham-operated control animals. Con, control; Hydro, hydrocephalus; TH, tyrosine hydroxylase; DR1 and DR2, type 1 and type 2 dopamine receptors; ChAT, choline acetyltransferase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase. *P < 0.05 and **P < 0.001 between the marked and the corresponding age-matched control. Scale bar = 100 μm

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Fluids and Barriers of the CNS

ISSN: 2045-8118