From: Age dependent contribution of entry via the CSF to the overall brain entry of small and large hydrophilic markers
30 s (μm)
5 min (μm)
5Â min diffusion distance/E19 cortex thickness (%)
5Â min diffusion distance/Adult cortex thickness (%)
Sucrose
205
648
88%
30%
Dextran
20
62
 × 
3%