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Table 3 Calculated approximate diffusion distance of dextran and sucrose in short experiments

From: Age dependent contribution of entry via the CSF to the overall brain entry of small and large hydrophilic markers

 

30 s (μm)

5 min (μm)

5 min diffusion distance/E19 cortex thickness (%)

5 min diffusion distance/Adult cortex thickness (%)

Sucrose

205

648

88%

30%

Dextran

20

62

 × 

3%

  1. Distances calculated as described in text. Thickness of cortex in E19 and adult rats provided in Additional file 1: Table S3. × indicates that the route into the brain is restricted against 70 kDa dextran in E19 due to strap junctions [10]