Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age

Hidaka, Yosuke; Hashimoto, Mamoru; Suehiro, Takashi; Fukuhara, Ryuji; Ishikawa, Tomohisa; Tsunoda, Naoko; Koyama, Asuka; Honda, Kazuki; Miyagawa, Yusuke; Yoshiura, Kazuhiro; Boku, Shuken; Ishii, Kazunari; Ikeda, Manabu; Takebayashi, Minoru

doi:10.1186/s12987-022-00381-5

Fluids and Barriers of the CNS

Table 4 Results of hierarchical multiple regression analysis for TUG with brain structures

From: Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age

	All individuals (n = 1,356)					Individuals without DESH (n = 1,331)
	Brain structure	β_STD	P-value	ΔR²		Brain structure	β_STD	P-value	ΔR²
1	Precentral	−0.1534	< 0.0001*	0.0128	1	Precentral	−0.1433	< 0.0001*	0.0112
2	Pars orbitalis	−0.1188	< 0.0001*	0.0120	2	Pars orbitalis	−0.1091	< 0.0001*	0.0101
3	Lateral orbitofrontal	−0.1227	< 0.0001*	0.0119	3	Lateral orbitofrontal	−0.1115	< 0.0001*	0.0100
4	Lingual	−0.1127	< 0.0001*	0.0104	4	Lingual	−0.1078	0.0001*	0.0095
5	Accumbens	−0.1163	< 0.0001*	0.0100	5	Superior parietal	−0.1148	0.0002*	0.0088
6	Superior parietal	−0.1216	< 0.0001*	0.0099	6	Accumbens	−0.1073	0.0003*	0.0085
7	Insula	−0.1123	0.0001*	0.0093	7	Insula	−0.1013	0.0006*	0.0076
8	Superior frontal	−0.1134	0.0002*	0.0086	8	Precuneus	−0.1040	0.0007*	0.0074
9	Superior temporal	−0.1082	0.0002*	0.0086	9	Superior frontal	−0.1050	0.0007*	0.0074
10	Supramarginal	−0.1049	0.0002*	0.0085	10	Middle temporal	−0.0983	0.0008*	0.0073
11	Posterior cingulate	−0.1032	0.0003*	0.0084	11	Superior temporal	−0.0970	0.0010*	0.0070
12	Middle temporal	−0.1056	0.0003*	0.0083	12	Supramarginal	−0.0934	0.0012	0.0068
13	Precuneus	−0.1075	0.0004*	0.0080	13	Inferior temporal	−0.0918	0.0012	0.0067
14	Pallidum	−0.0958	0.0005*	0.0076	14	Pallidum	−0.0878	0.0018	0.0063
15	Hippocampus	−0.1005	0.0009*	0.0069	15	Hippocampus	−0.0955	0.0018	0.0063
16	Inferior temporal	−0.0923	0.0010*	0.0068	16	Posterior cingulate	−0.0851	0.0028	0.0058
17	Transverse temporal	−0.0892	0.0011	0.0067	17	Corpus callosum	−0.0857	0.0039	0.0054
18	Corpus callosum	−0.0900	0.0022	0.0059	18	Banks sts	−0.0850	0.0040	0.0053
19	Banks sts	−0.0882	0.0024	0.0058	19	Caudate	−0.0822	0.0056	0.0050
20	Rostral anterior cingulate	−0.0790	0.0028	0.0056	20	Transverse temporal	−0.0736	0.0080	0.0045

After controlling for age, sex, education, hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, coronary artery disease, heart failure, BMI, history of smoking, MRI scanner, Fazekas score, lacunar infarction, microbleeds and perivascular space (Block 1), each brain structure was entered in Block 2. For each analysis, the top 20 brain structures are shown in descending order of ∆R²
^*The significance level was P < 0.0011 to correct for 46 modeling analyses
BMI body mass index, DESH disproportionately enlarged subarachnoid-space hydrocephalus, MMSE, Mini-Mental State Examination, SF Sylvian fissure, SHM subarachnoid space at high convexity and midline, TUG Timed Up and Go, VS ventricular system

Back to article page

ISSN: 2045-8118

Contact us

Submission enquiries: journalsubmissions@springernature.com