Skip to main content
Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Mucopolysaccharidoses and the blood–brain barrier

Fig. 1

Schematic representation of the RMT system and endosomal trafficking mechanisms in the brain endothelial cells. A Innate RMT systems available at the BBB. The cellular uptake of lysosomal enzymes in brain cells were mostly by CI-MPR in neurons, astrocytes, and oligodendrocytes. However, microglia show mannose and mannan mediations. TfR: Transferrin receptor; IR: Insulin receptor; LDLR: low-density lipoprotein receptor; insulin-like growth factor 1 receptor. B Intracellular vesicle trafficking and Rab small GTPases

Back to article page

Fluids and Barriers of the CNS

ISSN: 2045-8118