Fig. 1
From: ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells
Changes of 5hmC, ZO-1, and CD11b in Tet2-/- mice. A–D 5hmC signal in endothelial cells (arrow) of 8-week and 12-month old wild type and Tet2 KO mice. E Semi-quantitative analysis of 5hmC staining of brain endothelial cells in wild type and Tet2 KO mice. F–I ZO-1 expression by endothelial cells (arrow) of 8-week and 12-month old wild type and Tet2 KO mice. J Semi-quantitative analysis of ZO-1 expression by endothelial cells. K–N. CD11b signal in endothelial cells (arrow) of 8-week and 12-month old wild type and Tet2 KO mice. O Semi-quantitative analysis of CD11b expression by endothelial cells. Scale bars: 50 μm. All data were shown as the mean ± SEM. The p values were determined by the two-tailed t-test. Values of p < 0.05 were considered statistically significant. * and ** denoted p < 0.05 and p < 0.01, respectively