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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Characterization of passive permeability after low intensity focused ultrasound mediated blood–brain barrier disruption in a preclinical model

Fig. 5

Increase in BBB permeability post LIFU is transient and affects accumulation of drugs/tracers within the brain in a size dependent manner. A–C Time of drug/ tracer administration post LIFU significantly affects brain accumulation of tracers for AIB, TxRed and Cs Blue respectively. Peak BBB permeability is observed when tracer is administered before sonication or 6-h post-sonication. D Significantly higher brain accumulation is observed when tracer is administered on-board or pre-sonication vs when it is administered immediately post sonication. Increase in BBB permeability is influenced by size of administered tracer. (p < 0.01)

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Fluids and Barriers of the CNS

ISSN: 2045-8118