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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Characterization of passive permeability after low intensity focused ultrasound mediated blood–brain barrier disruption in a preclinical model

Fig. 2

Histological verification of opening of healthy BBB. A Coronal, Sagittal and axial MRI images of brain showing localization before sonication. B Coronal, Sagittal and axial MRI images showing gadaolinium contrast enhancement in sonicated regions of brain. C, D Enhancement in intensity of TxRed (625 Da), 10kD dye in sonicated region E Autoradiogram showing enhanced accumulation of C-14 aminoisobutyric acid (105 Da) in sonicated region. F Cresyl violet staining shows no macroscopic damage to brain. G Quantitative analysis shows significantly higher accumulation of AIB, TxRed and 10kD dextran compared to non-sonicated contralateral side (p < 0.01)

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Fluids and Barriers of the CNS

ISSN: 2045-8118