Fig. 8
From: Activation of NMDA receptors in brain endothelial cells increases transcellular permeability
Ablation of the NMDA receptor in the endothelial cells induces decreased level of neuronal cells in the brain and its survival is decreased. A Brains from the 3, 6, and 9 months old endothelial cell specific NR1 knock out (NR1fl/fl-Tie2Cre+) and its littermate control ((NR1fl/fl-Tie2Cre−) were fixed and sectioned to stain with NeuN (Red) a marker for neuronal cells. Scale bar indicates 400 μm. B Number of NeuN positive signals from cortices was quantified and depicted as a graph. (two-tailed unpaired student t-test, ** indicates where p < 0.01, 5 different area each from 3 different animals). C Survival rate of endothelial cell specific NR1 knockout and its littermate control was compared and depicted as a graph (** indicates where p < 0.01, Log-rank (Mantel-Cox) test)