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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: A transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption

Fig. 3

Gene set analysis of Notch1 signaling as a key regulator of BBB maintenance. A Comparison of GSVA scores of Notch1 signaling pathway genes. B Heatmap of Notch1 signaling pathway gene expression levels, determined by analyzing fold change (|FC|≥ 1.2) and p-value (≤ 0.1), in WT and KO groups (C) RPKM value of the Notch1 gene. Data are presented as means ± SD (*P < 0.05, **P < 0.01, ***P < 0.001 vs. WT). D, E Notch1 protein level in isolated brain microvessels from the TEKCRIF1 mouse (n = 8 mice). Data are presented as means ± SD from three independent experiments performed under the same conditions (*P < 0.05, **P < 0.01, ***P < 0.001 vs. WT)

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Fluids and Barriers of the CNS

ISSN: 2045-8118