Distinct volumetric features of cerebrospinal fluid distribution in idiopathic normal-pressure hydrocephalus and Alzheimer’s disease

Table 2 Results of measurement of the normalized CSF space volume

Region	Controls	INPH	AD	Statistical comparison
Region	(n = 26)	(n = 49)	(n = 59)	INPH versus controls	AD versus controls	INPH versus AD
Lateral ventricle^a	0.018 (0.015–0.024)	0.074 (0.066–0.085)	0.026 (0.020–0.034)	P < 0.001	P < 0.001	P < 0.001
High-convexity subarachnoid space^a	0.005 (0.004–0.006)	0.002 (0.001–0.003)	0.005 (0.004–0.007)	P < 0.001	P = 0.499	P < 0.001
CSF spaces of the Sylvian fissure region^a	0.013 (0.012–0.015)	0.022 (0.018–0.026)	0.017 (0.015–0.020)	P < 0.001	P < 0.001	P < 0.001

Data are presented as median (25–75th percentile, IQR) for non-normally distributed variables
Normalized volume = (regional volume)/(intracranial volume)
^aSignificant intergroup difference with Kruskal–Wallis analysis (P < 0.001)
INPH idiopathic normal-pressure hydrocephalus, AD Alzheimer’s disease, IQR interquartile range

ISSN: 2045-8118